NAXCOT-500 TAB

Naxcot-500 Tablets 

Brand: Naxcot-500
Manufacturer shown: Accott Healthcare
Dosage form: Tablet
Pack: 10 × 10 tablets

The pack identifies Naproxen Sodium + Domperidone. For the 500-strength formulation, the standard composition is Naproxen sodium 550 mg equivalent to naproxen 500 mg + Domperidone 10 mg. This composition is also documented for 500/10 mg naproxen–domperidone formulations. (Kerala DC)

IngredientAmount per tabletRoleNaproxen Sodium USP550 mgEquivalent to Naproxen 500 mg; NSAID for pain and inflammationDomperidone Maleate IPEquivalent to Domperidone 10 mgAnti-nausea/anti-vomiting medicine; also promotes gastric motilityExcipientsq.s.Tablet formation, stability and coating

1. Naproxen sodium — 550 mg

Equivalent to naproxen 500 mg.

• Non-steroidal anti-inflammatory drug (NSAID).

• Reduces pain, inflammation and swelling.

• Commonly used in migraine-related pain and other inflammatory/musculoskeletal pain.

• Naproxen works mainly by inhibiting COX enzymes, thereby reducing prostaglandin production.

The distinction is important: 550 mg refers to naproxen sodium salt, while its therapeutic equivalent is 500 mg naproxen. (Torrent Pharmaceuticals)

2. Domperidone — 10 mg

• Primarily an antiemetic.

• Helps control nausea and vomiting, which can accompany migraine.

• Also increases upper gastrointestinal motility and can help gastric emptying.

• It is included in this combination mainly to address the nausea/vomiting associated with migraine. (Abiba Pharmacia)

Excipients

The exact Accott Naxcot-500 excipient list is not visible in the supplied photograph, so it would not be appropriate to claim a manufacturer-specific list.

For comparison, a documented 500/10 mg naproxen–domperidone formulation contains excipients such as lactose, microcrystalline cellulose, starch, povidone, talc, magnesium stearate, colloidal silicon dioxide, sodium starch glycolate and coating ingredients. These should not be assumed to be the exact excipients in Naxcot-500. (Torrent Pharmaceuticals)

Main use

Naxcot-500 is primarily a pain-relieving + anti-nausea combination, particularly used for migraine attacks. (Torrent Pharmaceuticals)

Important precautions

• Naproxen can cause gastric irritation, ulcers and gastrointestinal bleeding, and can affect kidney function.

• Take it only as directed and preferably with/after food if advised.

• Domperidone can affect heart rhythm (QT prolongation) in susceptible people and has important dose/interaction precautions.

• Avoid combining Naxcot-500 with other NSAIDs such as diclofenac, ibuprofen, nimesulide or additional naproxen unless specifically prescribed.

In short: Naxcot-500 = Naproxen sodium 550 mg (equivalent to naproxen 500 mg) + Domperidone 10 mg per tablet + excipients q.s. (Kerala DC)