LINZCOT-600 TAB

LINZCOT-600 Tablets 

Brand: LINZCOT-600
Manufacturer shown: Accott Healthcare
Dosage form: Tablet
Strength: 600 mg
Pack shown: 10 × 10 tablets

Composition per tablet

IngredientAmount per tabletFunctionLinezolid IP600 mgOxazolidinone antibioticExcipientsq.s.Tablet manufacturing/stability

The package clearly states “Linezolid Tablets IP 600 mg.” Linezolid 600-mg tablets contain 600 mg linezolid per tablet. (Drug Database)

1. Linezolid — 600 mg

Linezolid is a synthetic oxazolidinone antibiotic. It inhibits bacterial protein synthesis, thereby preventing susceptible bacteria from growing. (DailyMed)

It is particularly active against certain Gram-positive bacteria, including organisms such as:

• Staphylococcus aureus, including MRSA

• Streptococcus species

• Enterococcus species, including certain vancomycin-resistant strains

It can be used for serious infections such as pneumonia and complicated skin/soft-tissue infections when the causative bacteria are susceptible. It is not effective against Gram-negative infections. (Drug Database)

Salt/chemical form

The active ingredient is linezolid itself, with a molecular weight of approximately 337.35 g/mol. The 600 mg on the label refers to 600 mg linezolid, not 600 mg of a different salt. (DailyMed)

Excipients

The exact Accott-specific excipient list cannot be confirmed from the front photograph. Different manufacturers use different inactive ingredients. For example, approved 600-mg linezolid products may contain combinations of microcrystalline cellulose, sodium starch glycolate, hydroxypropylcellulose, magnesium stearate and film-coating ingredients such as hypromellose, titanium dioxide and polyethylene glycol. (medicines.org.uk)

Therefore, I would not assume those ingredients are present in LINZCOT-600 without seeing its composition panel.

Important safety

Linezolid is a prescription/reserve antibiotic and should be used only under medical supervision.

Important potential problems with prolonged or inappropriate use include:

• Low blood counts, particularly thrombocytopenia

• Peripheral or optic neuropathy with prolonged treatment

• Lactic acidosis

• Important interactions with serotonergic medicines because linezolid has MAO-inhibiting activity

• Potential interaction with large amounts of tyramine-rich foods (apotex.com)

Final composition

LINZCOT-600 = Linezolid IP 600 mg per tablet + excipients q.s.

The complete excipient list and their quantities require a clear photograph of the back/side panel where the “Each tablet contains…” information is printed.